Wish You Well by David Baldacci.

In 1940, after a car accident kills their father and renders their mother mute and semi-paralyzed, twelve-year-old Lou and seven-year-old Oz go to remote Southwest Virginia to live with their great-grandmother on her farm. As New York City natives, they face many challenges in the foreign landscape — prejudice, poverty, death, how to have faith and a struggle for survival with a powerful coal company. The book, published in 2000, is based on the life of Baldacci's maternal ancestors in the Appalachian hills of Virginia. Wish You Well is a tender, touching story with a huge heart.

Look for the movie, "Wish You Well," in 2013, starring Josh Lucas ("Sweet Home Alabama"), Mackenzie Foy ("The Twilight Saga: Breaking Dawn") and Academy Award winner Ellen Burstyn! Shot in Southwest Virginia, the film is a collaboration between Life Out Loud Films, Baldacci Entertainment and Copper Beech Productions. David Baldacci is screenwriter and producer. http://www.facebook.com/pages/Wish-You-Well-Movie/112539582190705